Article
GWAS on family history of Alzheimer's disease.
Translational psychiatry - 18 May 2018
Marioni Riccardo E, Harris Sarah E, Zhang Qian, McRae Allan F, Hagenaars Saskia P, Hill W David, Davies Gail, Ritchie Craig W, Gale Catharine R, Starr John M, Goate Alison M, Porteous David J, Yang Jian, Evans Kathryn L, Deary Ian J, Wray Naomi R, Visscher Peter M
Abstract excerpt
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. We show that self-report of parental history of Alzheimer's dementia for case ascertainment in a genome-wide association study of 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases)...
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