Article
Analysis of intratumor heterogeneity in Neurofibromatosis type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.
Human mutation - 1 Aug 2018
Carrió Meritxell, Gel Bernat, Terribas Ernest, Zucchiatti Adriana Carolina, Moliné Teresa, Rosas Inma, Teulé Álex, Ramón Y Cajal Santiago, López-Gutiérrez Juan Carlos, Blanco Ignacio, Castellanos Elisabeth, Lázaro Conxi, Stemmer-Rachamimov Anat, Romagosa Cleofé, Serra Eduard
Abstract excerpt
Plexiform neurofibromas (PNFs) are benign peripheral nerve sheath tumors involving large nerves present in 30%-50% Neurofibromatosis type 1 (NF1) patients. Atypical neurofibromas (ANF) are distinct nodular lesions with atypical features on histology that arise from PNFs. The risk and timeline of malignant transformation in ANF is difficult to assess. A recent NIH workshop has stratified ANFs and separated a...
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