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Article

Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.

Genes - 1 May 2020

Moon Chang-In, Tompkins William, Wang Yuxi, Godec Abigail, Zhang Xiaochun, Pipkorn Patrik, Miller Christopher A, Dehner Carina, Dahiya Sonika, Hirbe Angela C

Abstract excerpt

Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral nerve sheath tumor (MPNST). Despite continued research, no effective therapies have emerged from...

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Identifiers

PMID: 32369930
DOI: 10.3390/genes11050499
PMCID: PMC7291009

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Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.PMID 32369930Read ↗

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