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Article

Subclassification of Nerve Sheath Tumors by Gene Expression Profiling

1 Jul 2004

Abstract excerpt

Nerve sheath tumors are the most common tumors of Neurofibromatosis type 1 (NF1) patients. Dermal neurofibromas develop in nearly all NF1-patients, whereas plexiform neurofibromas are only observed in one-third of the patients. NF1-patients have about a 10% lifetime risk for developing malignant pheripheral nerve sheath tumors (MPNST). The origin of these tumors is thought to be the Schwann cell lacking...

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PMID: 15446580
DOI: 10.1111/j.1750-3639.2004.tb00062.x

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