Article
Elucidating the genetic architecture of reproductive ageing in the Japanese population.
Nature communications - 17 May 2018
Horikoshi Momoko, Day Felix R, Akiyama Masato, Hirata Makoto, Kamatani Yoichiro, Matsuda Koichi, Ishigaki Kazuyoshi, Kanai Masahiro, Wright Hollis, Toro Carlos A, Ojeda Sergio R, Lomniczi Alejandro, Kubo Michiaki, Ong Ken K, Perry John R B
Abstract excerpt
Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured by common European genetic variation. Here, we report 26 loci (all P < 5 × 10-8) for reproductive ageing, i.e. puberty timing or age at menopause, in a non-European population (up to...
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