Article
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
Cell - 29 Jan 1993
Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, Bajorath J, Grosmaire L S, Stenkamp R, Neubauer M
Abstract excerpt
The prominent role of the CD40 receptor in B cell responses led us to investigate the role of the gp39-CD40 interaction in a group of primary immunodeficient patients with defective antibody production. Here we report that patients with hyper-IgM syndrome (HIM) have a defective gp39-CD40 interact...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Differentiation, T-Lymphocyte
- B-Lymphocytes
- Base Sequence
- Blotting, Northern
- CD40 Antigens
- CD40 Ligand
- Chromosome Mapping
- DNA
- Humans