Article
IMP3 promotes TNBC stem cell property through miRNA-34a regulation.
European review for medical and pharmacological sciences - 1 May 2018
Huang Q-D, Zheng S-R, Cai Y-J, Chen D-L, Shen Y-Y, Lin C-Q, Hu X-Q, Wang X-H, Shi H, Guo G-L
Abstract excerpt
OBJECTIVE: To explore the expression and function of insulin-like growth factor II (IGFII) mRNA binding protein (IMP3) in the Triple Negative Breast Cancer (TNBC). MATERIALS AND METHODS: According to previously reported gene expression array, we found that IMP3 had significantly higher expression in the CD44+CD24-ESA+ cell cluster, tumor initiating cell or cancer stem cell (CSCs), compared to other tumor cells....
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