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Article

BAG3 promotes stem cell-like phenotype in breast cancer by upregulation of CXCR4 via interaction with its transcript.

Cell death & disease - 13 Jul 2017

Liu Bao-Qin, Zhang Song, Li Si, An Ming-Xin, Li Chao, Yan Jing, Wang Jia-Mei, Wang Hua-Qin

Abstract excerpt

BAG3 is an evolutionarily conserved co-chaperone expressed at high levels and has a prosurvival role in many tumor types. The current study reported that BAG3 was induced under specific floating culture conditions that enrich breast cancer stem cell (BCSC)-like cells in spheres. Ectopic BAG3 overexpression increased CD44+/CD24- CSC subpopulations, first-generation and second-generation mammosphere formation,...

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Source

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Identifiers

PMID: 28703799
DOI: 10.1038/cddis.2017.324
PMCID: PMC5550869

Genes

BAG3
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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