Article
IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype.
Human pathology - 1 Nov 2009
Walter Otto, Prasad Manju, Lu Shaolei, Quinlan Robert M, Edmiston Kathryn L, Khan Ashraf
Abstract excerpt
IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. Basal-like carcinoma was initially identified by gene expression profiling. It accounts for 15% to...
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