Article
Coulomb and CH-π interactions in (6-4) photolyase-DNA complex dominate DNA binding and repair abilities.
Nucleic acids research - 27 Jul 2018
Terai Yuma, Sato Ryuma, Yumiba Takahiro, Harada Ryuhei, Shimizu Kohei, Toga Tatsuya, Ishikawa-Fujiwara Tomoko, Todo Takeshi, Iwai Shigenori, Shigeta Yasuteru, Yamamoto Junpei
Abstract excerpt
(6-4) Photolyases ((6-4)PLs) are flavoenzymes that repair the carcinogenic UV-induced DNA damage, pyrimidine(6-4)pyrimidone photoproducts ((6-4)PPs), in a light-dependent manner. Although the reaction mechanism of DNA photorepair by (6-4)PLs has been intensively investigated, the molecular mechanism of the lesion recognition remains obscure. We show that a well-conserved arginine residue in Xenopus laevis (6-4)PL...
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