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Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity.

Photochemistry and photobiology - 1 Jan 2017

Zhang Fan, Ma Hongju, Bowatte Kalinga, Kwiatkowski Dennis, Mittmann Esther, Qasem Heba, Krauß Norbert, Zeng Xiaoli, Ren Zhong, Scheerer Patrick, Yang Xiaojing, Lamparter Tilman

Abstract excerpt

PhrB from Agrobacterium fabrum is the first prokaryotic photolyase which repairs (6-4) UV DNA photoproducts. The protein harbors three cofactors: the enzymatically active FAD chromophore, a second chromophore, 6,7-dimethyl-8-ribityllumazine (DMRL) and a cubane-type Fe-S cluster. Tyr424 of PhrB is part of the DNA-binding site and could provide an electron link to the Fe-S cluster. The PhrBY424F mutant showed...

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PMID: 27992645
DOI: 10.1111/php.12699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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