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Article

Study on the Mechanism of Cell Cycle Checkpoint Kinase 2 (CHEK2) Gene Dysfunction in Chemotherapeutic Drug Resistance of Triple Negative Breast Cancer Cells.

Medical science monitor : international medical journal of experimental and clinical research - 15 May 2018

Luo Li, Gao Wei, Wang Jinghui, Wang Dingxue, Peng Xiaobo, Jia Zhaoyang, Jiang Ye, Li Gongzhuo, Tang Dongxin, Wang Yajie

Abstract excerpt

BACKGROUND This study aimed to investigate the mechanism of CHEK2 gene dysfunction in drug resistance of triple negative breast cancer (TNBC) cells. MATERIAL AND METHODS To perform our study, a stable CHEK2 wild type (CHEK2 WT) or CHEK2 Y390C mutation (CHEK2 Y390C) expressed MDA-MB-231 cell line was established. MTT assay, cell apoptosis assay and cell cycle assay were carried out to analyze the cell viability,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cisplatin

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Source

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Identifiers

PMID: 29761796
DOI: 10.12659/MSM.907256
PMCID: PMC5978023

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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