Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection.

doi:10.1093/infdis/jiy281

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Article

Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection.

The Journal of infectious diseases - 24 Aug 2018

Edwards Chelsea L, Ng Susanna S, Corvino Dillon, Montes de Oca Marcela, de Labastida Rivera Fabian, Nones Katia, Lakis Vanessa, Waddell Nicola, Amante Fiona H, McCarthy James S, Engwerda Christian R

Abstract excerpt

We examined transcriptional changes in CD4+ T cells during blood-stage Plasmodium falciparum infection in individuals without a history of previous parasite exposure. Transcription of CXCL8 (encoding interleukin 8) in CD4+ T cells was identified as an early biomarker of submicroscopic P. falciparum infection, with predictive power for parasite growth. Following antiparasitic drug treatment, a CD4+ T-cell...

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PMID: 29757416
DOI: 10.1093/infdis/jiy281

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CXCL8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.