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Different Facets of Aging in Human Mesenchymal Stem Cells

2 Mar 2010

Abstract excerpt

Mesenchymal stem cells (MSCs) have to be culture expanded to gain relevant cell numbers for therapeutic applications. However, within 2-3 months the proliferation rate of MSCs decays until they ultimately reach a senescent state. This is accompanied by enlarged morphology, reduced expression of surface markers, and decreased differentiation potential. So far it is only scarcely understood how long-term culture...

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PMID: 20196648
DOI: 10.1089/ten.teb.2009.0825

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