Article
GALNT12 is not a major contributor of familial colorectal cancer type X.
Human mutation - 1 Jan 2014
Seguí Nuria, Pineda Marta, Navarro Matilde, Lázaro Conxi, Brunet Joan, Infante Mar, Durán Mercedes, Soto José Luis, Blanco Ignacio, Capellá Gabriel, Valle Laura
Abstract excerpt
Previous evidence indicates that mutations in the GALNT12 gene might cause a fraction of the unexplained familial colorectal cancer (CRC) cases: GALNT12 is located in 9q22-33, in close proximity to a CRC linkage peak; and germline missense variants that reduce the enzymatic activity of the protein have been identified in CRC patients, some of them with familial CRC history. We hypothesized that mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.