Diseases associated with growth hormone-releasing hormone receptor (GHRHR) mutations.

doi:10.1016/S1877-1173(09)88003-4

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Article

Diseases associated with growth hormone-releasing hormone receptor (GHRHR) mutations.

Progress in molecular biology and translational science - 1 Jan 2009

Martari Marco, Salvatori Roberto

Abstract excerpt

The growth hormone (GH)-releasing hormone (GHRH) receptor (GHRHR) belongs to the G protein-coupled receptors family. It is expressed almost exclusively in the anterior pituitary, where it is necessary for somatotroph cells proliferation and for GH synthesis and secretion. Mutations in the human GHRHR gene (GHRHR) can impair ligand binding and signal transduction, and have been estimated to cause about 10% of...

Topics

Amino Acid Sequence
Animals
Disease
Genetic Predisposition to Disease
Humans
Molecular Sequence Data
Mutation
Polymorphism, Genetic
Receptors, Neuropeptide
Receptors, Pituitary Hormone-Regulating Hormone

Source

Open in PubMed

Identifiers

PMID: 20374725
DOI: 10.1016/S1877-1173(09)88003-4

Genes

GHRHR
GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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