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Article

Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.

Blood - 26 Jun 2014

Riches John C, O'Donovan Conor J, Kingdon Sarah J, McClanahan Fabienne, Clear Andrew J, Neuberg Donna S, Werner Lillian, Croce Carlo M, Ramsay Alan G, Rassenti Laura Z, Kipps Thomas J, Gribben John G

Abstract excerpt

The leukocyte adhesion cascade is important in chronic lymphocytic leukemia (CLL), as it controls migration of malignant cells into the pro-survival lymph node microenvironment. Circulating trisomy 12 CLL cells have increased expression of the integrins CD11a and CD49d, as well as CD38, but the t...

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Topics

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Share to Chromosomes, Human, Pair 12
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Integrins

Share to Neoplastic Cells, Circulating

Share to rap GTP-Binding Proteins

Share to Receptor, Notch1

Share to Trisomy

Source

Open in PubMed Open full text

Identifiers

PMID: 24829201
DOI: 10.1182/blood-2014-01-552307
PMCID: PMC4073326

Genes

NOTCH1
ITGB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24829201-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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