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Article

Cytomegalovirus subverts macrophage identity.

Cell - 8 Jul 2021

Baasch Sebastian, Giansanti Piero, Kolter Julia, Riedl André, Forde Aaron James, Runge Solveig, Zenke Simon, Elling Roland, Halenius Anne, Brabletz Simone, Hengel Hartmut, Kuster Bernhard, Brabletz Thomas, Cicin-Sain Luka, Arens Ramon, Vlachos Andreas, Rohr Jan Christopher, Stemmler Marc Philippe, Kopf Manfred, Ruzsics Zsolt, Henneke Philipp

Abstract excerpt

Cytomegaloviruses (CMVs) have co-evolved with their mammalian hosts for millions of years, leading to remarkable host specificity and high infection prevalence. Macrophages, which already populate barrier tissues in the embryo, are the predominant immune cells at potential CMV entry sites. Here we show that, upon CMV infection, macrophages undergo a morphological, immunophenotypic, and metabolic transformation...

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Identifiers

PMID: 34115982
DOI: 10.1016/j.cell.2021.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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