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Article

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.

Science translational medicine - 9 May 2018

Seltmann Kristin, Meyer Michael, Sulcova Jitka, Kockmann Tobias, Wehkamp Ulrike, Weidinger Stephan, Auf dem Keller Ulrich, Werner Sabine

Abstract excerpt

Low environmental humidity aggravates symptoms of the inflammatory skin disease atopic dermatitis (AD). Using mice that develop AD-like signs, we show that an increase in environmental humidity rescues their cutaneous inflammation and associated epidermal abnormalities. Quantitative proteomics analysis of epidermal lysates of mice kept at low or high humidity identified humidity-regulated proteins, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29743348
DOI: 10.1126/scitranslmed.aao4650

Genes

CLCA2

Provenance

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