Article
White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.
PloS one - 1 Jan 2018
Lee Seonjoo, Zimmerman Molly E, Narkhede Atul, Nasrabady Sara E, Tosto Giuseppe, Meier Irene B, Benzinger Tammie L S, Marcus Daniel S, Fagan Anne M, Fox Nick C, Cairns Nigel J, Holtzman David M, Buckles Virginia, Ghetti Bernardino, McDade Eric, Martins Ralph N, Saykin Andrew J, Masters Colin L, Ringman John M, Fӧrster Stefan, Schofield Peter R, Sperling Reisa A, Johnson Keith A, Chhatwal Jasmeer P, Salloway Stephen, Correia Stephen, Jack Clifford R, Weiner Michael, Bateman Randall J, Morris John C, Mayeux Richard, Brickman Adam M
Abstract excerpt
INTRODUCTION: White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of cerebrovascular disease, are a reflection of cerebral amyloid angiopathy (CAA) and that increased WMH in this population is a manifestation of this vascular form of...
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