Article
GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.
Neuron - 7 Feb 2008
Feinberg Evan H, Vanhoven Miri K, Bendesky Andres, Wang George, Fetter Richard D, Shen Kang, Bargmann Cornelia I
Abstract excerpt
The identification of synaptic partners is challenging in dense nerve bundles, where many processes occupy regions beneath the resolution of conventional light microscopy. To address this difficulty, we have developed GRASP, a system to label membrane contacts and synapses between two cells in living animals. Two complementary fragments of GFP are expressed on different cells, tethered to extracellular domains of...
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