Article
Predicting the Risk to Develop Preeclampsia in the First Trimester Combining Promoter Variant -98A/C of LGALS13 (Placental Protein 13), Black Ethnicity, Previous Preeclampsia, Obesity, and Maternal Age.
Fetal diagnosis and therapy - 1 Jan 2018
Madar-Shapiro Liora, Karady Ido, Trahtenherts Alla, Syngelaki Argryo, Akolekar Ranjit, Poon Liona, Cohen Ruth, Sharabi-Nov Adi, Huppertz Berthold, Sammar Marei, Juhasz Kata, Than Nandor Gabor, Papp Zoltan, Romero Roberto, Nicolaides Kypros H, Meiri Hamutal
Abstract excerpt
BACKGROUND: LGALS13 (placental protein 13 [PP13]) promoter DNA polymorphisms was evaluated in predicting preeclampsia (PE), given PP13's effects on hypotension, angiogenesis, and immune tolerance. METHODS: First-trimester plasma samples (49 term and 18 intermediate) of PE cases matched with 196 controls were collected from King's College Hospital, London, repository. Cell-free DNA was extracted and the LGALS13...
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