Article
mtDNA Haplogroup N9a Increases the Risk of Type 2 Diabetes by Altering Mitochondrial Function and Intracellular Mitochondrial Signals.
Diabetes - 1 Jul 2018
Fang Hezhi, Hu Nianqi, Zhao Qiongya, Wang Bingqian, Zhou Huaibin, Fu Qingzi, Shen Lijun, Chen Xiong, Shen Feixia, Lyu Jianxin
Abstract excerpt
Mitochondrial DNA (mtDNA) haplogroups have been associated with the incidence of type 2 diabetes (T2D); however, their underlying role in T2D remains poorly elucidated. Here, we report that mtDNA haplogroup N9a was associated with an increased risk of T2D occurrence in Southern China (odds ratio 1.999 [95% CI 1.229-3.251], P = 0.005). By using transmitochondrial technology, we demonstrated that the activity of...
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