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Article

Mitochondrial DNA associations with East Asian metabolic syndrome.

Biochimica et biophysica acta. Bioenergetics - 1 Sept 2018

Chalkia Dimitra, Chang Yi-Cheng, Derbeneva Olga, Lvova Maria, Wang Ping, Mishmar Dan, Liu Xiaogang, Singh Larry N, Chuang Lee-Ming, Wallace Douglas C

Abstract excerpt

Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), as have mitochondrial DNA (mtDNA) tRNA and duplication mutations and mtDNA haplogroup lineages. We identified 19 Taiwanese T2DM and MS pedigrees from Taiwan, with putative matrilineal transmission, one of which harbored the pathogenic mtDNA tRNALeu(UUR) nucleotide (nt) 3243A>G...

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Identifiers

PMID: 29997041
DOI: 10.1016/j.bbabio.2018.07.002
PMCID: PMC6530988

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