Article
Sub-optimal protection against past hepatitis B virus infection where subtype mismatch exists between vaccine and circulating viral genotype in northern Australia.
Vaccine - 7 Jun 2018
Cheah Benjamin C, Davies Jane, Singh Gurmeet R, Wood Nicholas, Jackson Kathy, Littlejohn Margaret, Davison Belinda, McIntyre Peter, Locarnini Stephen, Davis Joshua S, Tong Steven Y C
Abstract excerpt
BACKGROUND: In Australia's Northern Territory, the hepatitis B virus (HBV) subgenotype A2 (subtype adw2) vaccine was introduced in 1988 for Indigenous infants. Subsequently, the circulating viral genotype has been identified as subgenotype C4 (subtype ayw3). We assessed HBV vaccine effectiveness (VE) in light of this subtype mismatch. METHODS: Participants of the Aboriginal Birth Cohort (ABC) study were recruited...
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