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Article

Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies.

Birth defects research - 17 Jul 2018

Dong Yuqi, Wang Linlin, Lei Yunping, Yang Na, Cabrera Robert M, Finnell Richard H, Ren Aiguo

Abstract excerpt

BACKGROUND: Folate receptors (FRs) facilitate embryonic uptake of folates and are important for proper early embryonic development. There is accumulating evidence that blocking FR autoantibodies contribute to developmental diseases. However, genetic factors associated with the expression of FR autoantibodies remain unknown. OBJECTIVE: We investigated the effects of genetic polymorphisms in folate pathway genes on...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29732742
DOI: 10.1002/bdr2.1334
PMCID: PMC6276117

Genes

MTHFD2
MTHFR
DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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