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Article

A genome-wide association study for extremely high intelligence.

Molecular psychiatry - 1 May 2018

Zabaneh D, Krapohl E, Gaspar H A, Curtis C, Lee S H, Patel H, Newhouse S, Wu H M, Simpson M A, Putallaz M, Lubinski D, Plomin R, Breen G

Abstract excerpt

We used a case-control genome-wide association (GWA) design with cases consisting of 1238 individuals from the top 0.0003 (~170 mean IQ) of the population distribution of intelligence and 8172 unselected population-based controls. The single-nucleotide polymorphism heritability for the extreme IQ trait was 0.33 (0.02), which is the highest so far for a cognitive phenotype, and significant genome-wide genetic...

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Identifiers

PMID: 29731509
DOI: 10.1038/mp.2017.121
PMCID: PMC5987166

Genes

ADAM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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