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Article

CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study.

Circulation. Cardiovascular genetics - 1 Jun 2010

Rankinen Tuomo, Argyropoulos George, Rice Treva, Rao D C, Bouchard Claude

Abstract excerpt

BACKGROUND: A genome-wide linkage scan identified a quantitative trait locus for exercise training-induced changes in submaximal exercise (50 W) heart rate (DeltaHR50) on chromosome 2q33.3-q34 in the HERITAGE Family Study (n=472). METHODS AND RESULTS: To fine-map the region, 1450 tag SNPs were genotyped between 205 and 215 Mb on chromosome 2. The strongest evidence of association with DeltaHR50 was observed with...

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Share to Alleles
Share to Chromosomes, Human, Pair 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Exercise

Share to Heart Rate

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Regression Analysis

Source

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Identifiers

PMID: 20407090
DOI: 10.1161/CIRCGENETICS.109.925644
PMCID: PMC3045864

Genes

ERBB4
FASTKD2
IKZF2
MAP2
SPAG16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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