Article
Familial isolated pituitary adenomas experience at a single center: clinical importance of AIP mutation screening.
Arquivos brasileiros de endocrinologia e metabologia - 1 Nov 2010
Pinho Leandro Kasuki Jomori de, Vieira Neto Leonardo, Wildemberg Luiz Eduardo Armondi, Moraes Aline Barbosa, Takiya Christina M, Frohman Lawrence A, Korbonits Márta, Gadelha Mônica R
Abstract excerpt
We present four FIPA kindred discussing clinical and molecular data and emphasizing the differences regarding AIP status, as well as the importance of genetic screening. Family 1 consists of five patients harboring somatotropinomas with germline E24X mutation in AIP. In one of the patients, acromegaly was diagnosed through active screening, being cured by surgery. Families 2 and 3 are composed of two patients...
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