Article
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
Molecular genetics and metabolism - 1 Jun 2018
Angarita Stephanie A K, Truong Brian, Khoja Suhail, Nitzahn Matthew, Rajbhandari Abha K, Zhuravka Irina, Duarte Sergio, Lin Michael G, Lam Alex K, Cederbaum Stephen D, Lipshutz Gerald S
Abstract excerpt
The transplantation, engraftment, and expansion of primary hepatocytes have the potential to be an effective therapy for metabolic disorders of the liver including those of nitrogen metabolism. To date, such methods for the treatment of urea cycle disorders in murine models has only been minimally explored. Arginase deficiency, an inherited disorder of nitrogen metabolism that presents in the first two years of...
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