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Article

A mouse model of argininosuccinic aciduria: biochemical characterization.

Molecular genetics and metabolism - 1 Jan 2003

Reid Sutton V, Pan Yanzhen, Davis Erica C, Craigen William J

Abstract excerpt

Argininosuccinate lyase (AL) has several roles in intermediary metabolism. It is an essential component of the urea cycle, providing a pathway for the disposal of excess nitrogen in mammals. AL links the urea cycle to the tricarboxylic acid (TCA) cycle by generating fumarate. Finally, AL is required for the endogenous production of arginine. In this latter role it may function outside ureagenic organs to provide...

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Identifiers

PMID: 12559843
DOI: 10.1016/s1096-7192(02)00206-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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