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Article

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice.

PloS one - 1 Jan 2015

Ballantyne Laurel L, Sin Yuan Yan, St Amand Tim, Si Joshua, Goossens Steven, Haenebalcke Lieven, Haigh Jody J, Kyriakopoulou Lianna, Schulze Andreas, Funk Colin D

Abstract excerpt

Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body. Arginase-1 deficiency leads to hyperargininemia in mice and man with severe lethal consequences in the former and progressive neurological impairment to varying degrees in the latter. In a tamoxifen-induced arginase-1 deficient mouse model, mice succumb to...

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Identifiers

PMID: 25938595
DOI: 10.1371/journal.pone.0125967
PMCID: PMC4418594

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