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Article

Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.

Nature communications - 30 Apr 2018

Lobanova Ekaterina S, Finkelstein Stella, Li Jing, Travis Amanda M, Hao Ying, Klingeborn Mikael, Skiba Nikolai P, Deshaies Raymond J, Arshavsky Vadim Y

Abstract excerpt

Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent, i.e., targeting common pathological conditions arising from many disease-causing mutations. Previous studies revealed that one such condition is an insufficiency of the ubiquitin-proteasome system to...

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Identifiers

PMID: 29712894
DOI: 10.1038/s41467-018-04117-8
PMCID: PMC5928105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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