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Article

SCN5A mutation type and topology are associated with the risk of ventricular arrhythmia by sodium channel blockers.

International journal of cardiology - 1 Sept 2018

Amin Ahmad S, Reckman Yolan J, Arbelo Elena, Spanjaart Anne M, Postema Pieter G, Tadros Rafik, Tanck Michael W, Van den Berg Maarten P, Wilde Arthur A M, Tan Hanno L

Abstract excerpt

BACKGROUND: Ventricular fibrillation in patients with Brugada syndrome (BrS) is often initiated by premature ventricular contractions (PVCs). Presence of SCN5A mutation increases the risk of PVCs upon exposure to sodium channel blockers (SCB) in patients with baseline type-1 ECG. In patients without baseline type-1 ECG, however, the effect of SCN5A mutation on the risk of SCB-induced arrhythmia is unknown. We...

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Identifiers

PMID: 29709244
DOI: 10.1016/j.ijcard.2017.09.010

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