Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge.

doi:10.1093/europace/euag014

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Article

Clinical profile and prognosis of brugada syndrome SCN5A variant carriers with negative sodium channel blocker challenge.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 10 Mar 2026

Surget Elodie, Clerici Gael, Sacher Frédéric, Martins Raphael, Maury Philippe, Denjoy Isabelle, Thollet Aurélie, Barc Julien, Schott Jean Jacques, Drapier Nathalie, Redon Richard, Gourraud Jean Baptiste, Probst Vincent

Abstract excerpt

AIMS: Loss-of-function (LOF) variants in SCN5A are associated with Brugada syndrome (BrS), progressive conduction slowing, and other arrhythmias. While the prognosis of SCN5A carriers with a positive sodium channel blocker challenge (SCBC) is established, data on those with negative SCBC are limited. OBJECTIVE: To assess the clinical presentation and prognosis of SCN5A variant carriers with negative SCBC, and...

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Identifiers

PMID: 41812135
DOI: 10.1093/europace/euag014
PMCID: PMC12978426

Genes

SCN5A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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