Article
Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 1 Jul 2011
Amin Ahmad S, Boink Gerard J J, Atrafi Florence, Spanjaart Anne M, Asghari-Roodsari Alaleh, Molenaar Remco J, Ruijter Jan M, Wilde Arthur A M, Tan Hanno L
Abstract excerpt
AIMS: Brugada syndrome (BrS) is associated with increased risk for atrial fibrillation (AFib). However, the role of SCN5A mutations in the occurrence of AFib remains unclear. Cardiac sodium current reduction caused by SCN5A mutations may facilitate AFib by slowing intra-atrial conduction and inducing structural changes, but also prevent it by suppressing atrial ectopic activity. Here, we examined the relation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.