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The Mechanism of Ajmaline and Thus Brugada Syndrome: Not Only the Sodium Channel!

23 Dec 2021

Abstract excerpt

Ajmaline is an anti-arrhythmic drug that is used to unmask the type-1 Brugada syndrome (BrS) electrocardiogram pattern to diagnose the syndrome. Thus, the disease is defined at its core as a particular response to this or other drugs. Ajmaline is usually described as a sodium-channel blocker, and most research into the mechanism of BrS has centered around this idea that the sodium channel is somehow impaired in...

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PMID: 35004896
DOI: 10.3389/fcvm.2021.782596

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