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To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis

19 Mar 2015

Abstract excerpt

Epstein-Barr virus (EBV), a γ-herpesvirus, was the first human tumor virus discovered fifty years ago in endemic Burkitt lymphoma [1].Surprisingly, EBV was subsequently recognized to be a ubiquitous virus infecting greater than 90% of adults worldwide.In healthy children, primary EBV infection is typically asymptomatic because of a robust T cell immune response.However, infection during adolescence or later can...

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PMID: 25790223
DOI: 10.1371/journal.ppat.1004656

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