Article
Genome-wide linkage analysis in Spanish melanoma-prone families identifies a new familial melanoma susceptibility locus at 11q.
European journal of human genetics : EJHG - 1 Aug 2018
Potrony Miriam, Puig-Butille Joan Anton, Farnham James M, Giménez-Xavier Pol, Badenas Celia, Tell-Martí Gemma, Aguilera Paula, Carrera Cristina, Malvehy Josep, Teerlink Craig C, Puig Susana
Abstract excerpt
The main genetic factors for familial melanoma remain unknown in >75% of families. CDKN2A is mutated in around 20% of melanoma-prone families. Other high-risk melanoma susceptibility genes explain <3% of families studied to date. We performed the first genome-wide linkage analysis in CDKN2A-negative Spanish melanoma-prone families to identify novel melanoma susceptibility loci. We included 68 individuals from 2,...
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