Article
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.
Cell death & disease - 1 May 2018
Yan Bin, Liu Shuang, Shi Ying, Liu Na, Chen Ling, Wang Xiang, Xiao Desheng, Liu Xiaoli, Mao Chao, Jiang Yiqun, Lai Weiwei, Xin Xing, Tang Can-E, Luo Dixian, Tan Tan, Jia Jiantao, Liu Yating, Yang Rui, Huang Jun, Zhou Hu, Cheng Yan, Cao Ya, Yu Weishi, Muegge Kathrin, Tao Yongguang
Abstract excerpt
Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes...
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