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RAN/RANBP2 polymorphisms and neuroblastoma risk in Chinese children: a three-center case-control study.

Aging - 28 Apr 2018

Wang Juxiang, Zhuo Zhenjian, Chen Min, Zhu Jinhong, Zhao Jie, Zhang Jiao, Chen Shanshan, He Jing, Zhou Haixia

Abstract excerpt

The genetic etiology of sporadic neuroblastoma remains largely obscure. RAN and RANBP2 genes encode Ras-related nuclear protein and Ran-binding protein 2, respectively. These two proteins form Ran-RanBP2 complex that regulate various cellular activities including nuclear transport. Aberrant functions of the two proteins are implicated in carcinogenesis. Given the unknown role of RAN/RANBP2 single nucleotide...

Topics

Asian People
Case-Control Studies
Child
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Molecular Chaperones
Neuroblastoma
Nuclear Pore Complex Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Odds Ratio

Polymorphism, Single Nucleotide

ran GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29706609
DOI: 10.18632/aging.101429
PMCID: PMC5940104

Genes

RAN
RANBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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