Article
NRAS rs2273267 A>T polymorphism reduces neuroblastoma risk in Chinese children.
Gene - 15 Feb 2020
Li Suhong, Zhuo Zhenjian, Chang Xinghong, Ma Yan, Zhou Haixia, Zhang Jiao, Cheng Jiwen, He Jing, Li Yangyang
Abstract excerpt
Neuroblastoma is an extracranial solid tumor that mainly occurs in childhood. Mutations of NRAS gene have been described in several cancers. However, whether NRAS gene polymorphisms can predict the risk of neuroblastoma have not been investigated. We hypothesized that variations of NRAS gene contribute to neuroblastoma predisposition. Therefore, we conducted a multi-center case-control study using 263 cases and...
Topics
- Alleles
- Asian People
- Case-Control Studies
- Child
- Child, Preschool
- China
- Female
- GTP Phosphohydrolases
- Gene Frequency
- Genes, ras
- Genetic Predisposition to Disease