Article
A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2018
Li Wen, Fan Chun Chieh, Mäki-Marttunen Tuomo, Thompson Wesley K, Schork Andrew J, Bettella Francesco, Djurovic Srdjan, Dale Anders M, Andreassen Ole A, Wang Yunpeng
Abstract excerpt
Traditional genome-wide association studies (GWAS) have successfully detected genetic variants associated with schizophrenia. However, only a small fraction of heritability can be explained. Gene-set/pathway-based methods can overcome limitations arising from single nucleotide polymorphism (SNP)-based analysis, but most of them place constraints on size which may exclude highly specific and functional sets, like...
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