Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas.

The Journal of pathology - 1 Jul 2018

Feng Jie, Zhang Qi, Li Chuzhong, Zhou Yang, Zhao Sida, Hong Lichuan, Song Qi, Yu Shenyuan, Hu Chunxiu, Wang Herui, Mao Chengyuan, Shepard Matthew J, Hao Shuyu, Dominah Gifty, Sun Mitchell, Wan Hong, Park Deric M, Gilbert Mark R, Xu Guowang, Zhuang Zhengping, Zhang Yazhuo

Abstract excerpt

Oncocytomas represent a subset of benign pituitary adenomas that are characterized by significant mitochondrial hyperplasia. Mitochondria are key organelles for energy generation and metabolic intermediate production for biosynthesis in tumour cells, so understanding the mechanism underlying mitochondrial biogenesis and its impact on cellular metabolism in oncocytoma is vital. Here, we studied surgically resected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Adenoma, Oxyphilic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to Glycolysis

Share to L-Lactate Dehydrogenase

Share to Organelle Biogenesis

Share to Oxidative Phosphorylation

Share to Pituitary Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29704241
DOI: 10.1002/path.5090
PMCID: PMC7987132

Genes

LDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas.PMID 29704241Read ↗

Molecular and metabolic features of oncocytomas: Seeking the blueprints of indolent cancers.Semantic proximity Read ↗

Oxidative Phosphorylation Patterns in Pituitary Adenoma/Neuroendocrine TumorsSemantic proximity Read ↗

Oxidative phosphorylation patterns in pituitary adenoma/neuroendocrine tumors.Semantic proximity Read ↗

The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization.Semantic proximity Read ↗

Unravelling the Tumourigenesis Mechanisms of Oncocytic Cell Tumours: Discoveries from a Comparative Omics StudySemantic proximity Read ↗

Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background.Semantic proximity Read ↗

FLCN-mutated oncocytic tumor in the thyroid defines a biologically distinct subset characterized by metabolic remodeling and canonical oncogenic signaling suppression.Semantic proximity Read ↗

The importance of mitochondria in the tumourigenic phenotype: gliomas as the paradigm (review).Semantic proximity Read ↗

Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.Semantic proximity Read ↗

Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk NeuroblastomaSemantic proximity Read ↗

Splicing Machinery is Dysregulated in Pituitary Neuroendocrine Tumors and is Associated with Aggressiveness FeaturesSemantic proximity Read ↗

Depleting glioblastoma cells of very long-chain acyl-CoA synthetase 3 (ACSVL3) produces metabolic alterations in non-lipid pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.