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Detection of circulating Mycobacterium tuberculosis -specific DNA by droplet digital PCR for vaccine evaluation in challenged monkeys and TB diagnosis

24 Apr 2018

Abstract excerpt

Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development of an effective and sensitive detection method is urgently needed for bacterial load evaluation in vaccine development, early TB diagnosis, and TB treatment. Droplet digital polymerase chain reaction (ddPCR) is a newly...

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PMID: 29691363
DOI: 10.1038/s41426-018-0076-3

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