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Article

Estrogen Receptor β-Selective Transcriptional Activity and Recruitment of Coregulators by Phytoestrogens

1 May 2001

Abstract excerpt

Estrogens used in hormone replacement therapy regimens may increase the risk of developing breast cancer. Paradoxically, high consumption of plant-derived phytoestrogens, particularly soybean isoflavones, is associated with a low incidence of breast cancer. To explore the molecular basis for these potential different clinical outcomes, we investigated whether soybean isoflavones elicit distinct transcriptional...

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PMID: 11279159
DOI: 10.1074/jbc.m100953200

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