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Article

[Pathophysiology of myelodysplastic syndromes].

Bulletin du cancer - 1 Nov 2023

Fontenay Michaela, Boussaid Ismael, Chapuis Nicolas

Abstract excerpt

During aging, the onset of mutations at low frequency in hematopoietic cells or clonal hematopoiesis of indeterminate significance favors the evolution towards hemopathies such as myelodysplastic syndromes or acute leukemias, but also cardiovascular diseases and other pathologies. Acute or chronic inflammation related to age influences the clonal evolution and the immune response. Conversely, mutated...

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PMID: 37423830
DOI: 10.1016/j.bulcan.2023.02.026

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