Article
Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.
Genomics - 1 Jul 2019
Matana Antonela, Popović Marijana, Boutin Thibaud, Torlak Vesela, Brdar Dubravka, Gunjača Ivana, Kolčić Ivana, Boraska Perica Vesna, Punda Ante, Polašek Ozren, Hayward Caroline, Barbalić Maja, Zemunik Tatijana
Abstract excerpt
Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific...
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