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Article

A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.

The Journal of clinical endocrinology and metabolism - 1 May 2015

Schultheiss Ulla T, Teumer Alexander, Medici Marco, Li Yong, Daya Natalie, Chaker Layal, Homuth Georg, Uitterlinden Andre G, Nauck Matthias, Hofman Albert, Selvin Elizabeth, Völzke Henry, Peeters Robin P, Köttgen Anna

Abstract excerpt

CONTEXT: Antibodies against thyroid peroxidase (TPOAbs) are detected in 90% of all patients with Hashimoto thyroiditis, the most common cause of hypothyroidism. Hypothyroidism is associated with a range of adverse outcomes. The current knowledge of its genetic underpinnings is limited. OBJECTIVE: The purpose of this study was to identify novel genetic variants associated with TPOAb concentrations and positivity...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 25719932
DOI: 10.1210/jc.2014-4352
PMCID: PMC4422885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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