Article
Immune aspects of the pathogenesis of inflammatory bowel disease.
Pharmacology & therapeutics - 1 Mar 2013
Hisamatsu Tadakazu, Kanai Takanori, Mikami Yohei, Yoneno Kazuaki, Matsuoka Katsuyoshi, Hibi Toshifumi
Abstract excerpt
Although the precise etiologies of inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) remain obscure, several reports have indicated that dysfunction of the mucosal immune system plays an important role in its pathogenesis. Recent progress with genome-wide association studies has identified many IBD susceptibility genes. In individuals with genetic risk, abnormal interactions between the...
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